Info
| ID | 448 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "P": 1, "O": 1} |
| Abbreviation | 2 |
| SMILES | C1N2CN3CN1CP(C2)C3.Cc1ccc(C(C)C)cc1.[O-]n1ccccc1=S |
TUCAN
C21N4OPRuS/(1-11)(2-11)(3-13)(4-9)(4-12)(5-7)(5-21)(6-10)(6-12)(7-8)(8-14)(9-13)(10-13)(11-12)(14-25)(15-22)(15-23)(16-22)(16-24)(17-23)(17-24)(18-22)(18-27)(19-23)(19-27)(20-24)(20-27)(21-25)(21-28)(25-26)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 3.7 | — | 10.1002/chem.201903109 | 2019 |
| SK-OV-3 | 9.2 | — | 10.1002/chem.201903109 | 2019 |
| OE19 | 12 | — | 10.1002/chem.201903109 | 2019 |
| HCT-116 | 14 | — | 10.1002/chem.201903109 | 2019 |
| PC-3 | 21 | — | 10.1002/chem.201903109 | 2019 |
| HepG2 | 22 | — | 10.1002/chem.201903109 | 2019 |
| SW626 | 30 | — | 10.1002/chem.201903109 | 2019 |
| COLO-205 | — | — | 10.3390/ph14060518 | 2021 |
| COLO-320 | — | — | 10.3390/ph14060518 | 2021 |
| MRC-5 | — | — | 10.3390/ph14060518 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 5 was also reported to be cytotoxic against a series of human cancer cells and induced caspase-dependent cell death in leukemia cells [17].»