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Complex #4479 — Ru(2) [MA-bpy-Ru]

2D Structure

Structure
⬇ MOL V3000

Info

ID4479
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 4}
AbbreviationMA-bpy-Ru
SMILESCc1ccc(C(C)C)cc1.Cc1ccnc(-c2cc(CNC(=O)c3ccccc3Nc3c(Cl)ccc(C)c3Cl)ccn2)c1.[Cl-]

TUCAN

C36H36Cl2N4ORu/(1-41)(2-64)(3-39)(4-39)(5-52)(6-44)(7-37)(8-37)(9-37)(10-39)(11-40)(12-54)(13-38)(14-43)(15-42)(16-41)(17-65)(18-38)(19-49)(20-47)(21-41)(22-50)(23-51)(24-63)(25-55)(26-48)(27-46)(28-65)(29-38)(30-45)(31-40)(32-62)(33-40)(34-53)(35-74)(36-73)(37-56)(38-58)(39-62)(40-62)(41-61)(42-43)(42-49)(43-51)(44-52)(44-56)(45-53)(45-56)(46-61)(46-67)(47-60)(47-63)(48-50)(48-71)(49-68)(50-58)(51-57)(52-59)(53-59)(54-60)(54-69)(55-61)(55-64)(57-68)(57-70)(58-72)(59-62)(60-65)(63-75)(64-76)(65-74)(66-71)(66-72)(66-73)(67-69)(67-76)(68-73)(69-75)(70-74)(70-77)(71-78)(72-79)(75-80)(76-80)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MCF-76.4 10.1039/d3dt00282a 2023
MDA-MB-23112 10.1039/d3dt00282a 2023
K-56214 10.1039/d3dt00282a 2023
NB414 10.1039/d3dt00282a 2023
HLF 10.1039/d3dt00282a 2023

🧬 Cell Death Types (1)

Autophagy high
«MA-bpy-Ru showed significantly high selectivity and cytotoxicity towards MCF-7 cells through the autophagic pathway»