Info
| ID | 4479 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | MA-bpy-Ru |
| SMILES | Cc1ccc(C(C)C)cc1.Cc1ccnc(-c2cc(CNC(=O)c3ccccc3Nc3c(Cl)ccc(C)c3Cl)ccn2)c1.[Cl-] |
TUCAN
C36H36Cl2N4ORu/(1-41)(2-64)(3-39)(4-39)(5-52)(6-44)(7-37)(8-37)(9-37)(10-39)(11-40)(12-54)(13-38)(14-43)(15-42)(16-41)(17-65)(18-38)(19-49)(20-47)(21-41)(22-50)(23-51)(24-63)(25-55)(26-48)(27-46)(28-65)(29-38)(30-45)(31-40)(32-62)(33-40)(34-53)(35-74)(36-73)(37-56)(38-58)(39-62)(40-62)(41-61)(42-43)(42-49)(43-51)(44-52)(44-56)(45-53)(45-56)(46-61)(46-67)(47-60)(47-63)(48-50)(48-71)(49-68)(50-58)(51-57)(52-59)(53-59)(54-60)(54-69)(55-61)(55-64)(57-68)(57-70)(58-72)(59-62)(60-65)(63-75)(64-76)(65-74)(66-71)(66-72)(66-73)(67-69)(67-76)(68-73)(69-75)(70-74)(70-77)(71-78)(72-79)(75-80)(76-80)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 6.4 | — | 10.1039/d3dt00282a | 2023 |
| MDA-MB-231 | 12 | — | 10.1039/d3dt00282a | 2023 |
| K-562 | 14 | — | 10.1039/d3dt00282a | 2023 |
| NB4 | 14 | — | 10.1039/d3dt00282a | 2023 |
| HLF | — | — | 10.1039/d3dt00282a | 2023 |
🧬 Cell Death Types (1)
Autophagy
high
«MA-bpy-Ru showed significantly high selectivity and cytotoxicity towards MCF-7 cells through the autophagic pathway»