Info
| ID | 4478 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru-2 |
| SMILES | c1cnc2c(c1)c1nc(-c3ccncc3)[nH]c1c1cccnc12.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C42H27N9Ru/(1-53)(2-30)(3-31)(4-54)(5-28)(6-39)(7-35)(8-57)(9-58)(10-29)(11-36)(12-34)(13-37)(14-42)(15-40)(16-55)(17-41)(18-44)(19-59)(20-38)(21-32)(22-56)(23-60)(24-33)(25-43)(26-45)(27-72)(28-35)(28-46)(29-30)(29-53)(30-46)(31-36)(31-47)(32-33)(32-55)(33-49)(34-48)(34-56)(35-47)(36-54)(37-39)(37-57)(38-43)(38-50)(39-50)(40-48)(40-60)(41-42)(41-51)(42-58)(43-51)(44-45)(44-52)(45-59)(46-61)(47-62)(48-69)(49-63)(49-68)(50-64)(51-65)(52-66)(52-67)(53-73)(54-74)(55-70)(56-71)(57-75)(58-78)(59-76)(60-71)(61-62)(61-73)(62-74)(63-66)(63-72)(64-65)(64-75)(65-78)(66-77)(67-68)(67-76)(68-70)(69-72)(69-77)(73-79)(74-79)(75-79)(76-79)(77-79)(78-79)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 44 | — | 10.3389/fchem.2022.890925 | 2022 |
| HepG2 | — | — | 10.3389/fchem.2022.890925 | 2022 |
| A549 | — | — | 10.3389/fchem.2022.890925 | 2022 |
| A549cisR | — | — | 10.3389/fchem.2022.890925 | 2022 |
| LO2 | — | — | 10.3389/fchem.2022.890925 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«The anticancer mechanistic studies reveal that RuRe-1 and RuRe-2 can induce apoptosis through the regulation of cell cycle, depolarization of mitochondrial membrane potential (MMP), elevation of intra...»