Info
| ID | 4477 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru-1 |
| SMILES | c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1.c1cnc2c(c1)c1nc(-c3ccncc3)[nH]c1c1cccnc12 |
TUCAN
C38H27N9Ru/(1-32)(2-33)(3-31)(4-34)(5-36)(6-29)(7-37)(8-50)(9-28)(10-41)(11-42)(12-51)(13-30)(14-35)(15-38)(16-49)(17-52)(18-39)(19-54)(20-53)(21-43)(22-40)(23-44)(24-55)(25-56)(26-45)(27-68)(28-47)(28-50)(29-33)(29-58)(30-31)(30-49)(31-48)(32-33)(32-51)(34-36)(34-54)(35-43)(35-55)(36-37)(37-59)(38-39)(38-52)(39-46)(40-47)(40-53)(41-43)(41-60)(42-44)(42-64)(44-45)(45-56)(46-57)(46-62)(47-65)(48-61)(48-63)(49-66)(50-67)(51-69)(52-73)(53-67)(54-70)(55-71)(56-72)(57-61)(57-73)(58-59)(58-69)(59-70)(60-64)(60-71)(61-66)(62-63)(62-74)(63-68)(64-72)(65-68)(65-74)(69-75)(70-75)(71-75)(72-75)(73-75)(74-75)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 40 | — | 10.3389/fchem.2022.890925 | 2022 |
| HepG2 | — | — | 10.3389/fchem.2022.890925 | 2022 |
| A549 | — | — | 10.3389/fchem.2022.890925 | 2022 |
| A549cisR | — | — | 10.3389/fchem.2022.890925 | 2022 |
| LO2 | — | — | 10.3389/fchem.2022.890925 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«The anticancer mechanistic studies reveal that RuRe-1 and RuRe-2 can induce apoptosis through the regulation of cell cycle, depolarization of mitochondrial membrane potential (MMP), elevation of intra...»