Info
| ID | 4475 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 4} |
| Abbreviation | 4 |
| SMILES | O=Cc1cc(Cl)cc(Cl)c1[O-].c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C27H19Cl2N4O2Ru/(1-21)(2-35)(3-20)(4-36)(5-37)(6-38)(7-22)(8-25)(9-24)(10-30)(11-27)(12-23)(13-26)(14-28)(15-43)(16-29)(17-31)(18-32)(19-33)(20-21)(20-35)(21-23)(22-27)(22-36)(23-39)(24-45)(24-46)(25-34)(25-46)(26-27)(26-40)(28-31)(28-41)(29-33)(29-42)(30-31)(30-37)(32-33)(32-38)(34-43)(34-44)(35-47)(36-48)(37-49)(38-50)(39-40)(39-47)(40-48)(41-42)(41-49)(42-50)(43-52)(44-45)(44-51)(45-54)(46-53)(47-55)(48-55)(49-55)(50-55)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.7 | — | 10.1039/d2dt00401a | 2022 |
| SW480 | 1.7 | — | 10.1039/d2dt00401a | 2022 |
| A549 | 2.8 | — | 10.1039/d2dt00401a | 2022 |
| HEK293 | 4.3 | — | 10.1039/d2dt00401a | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«"All complexes induce cell cycle arrest in G0/G1 and apoptosis" (Abstract) and "Anyway, all Ru(II) complexes induce apoptosis as a cell death mechanism in A549 cells" (Results, Apoptosis studies)»