Info
| ID | 4474 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 4} |
| Abbreviation | 3 |
| SMILES | O=Cc1cc(Cl)ccc1[O-].c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C27H20ClN4O2Ru/(1-22)(2-24)(3-37)(4-38)(5-39)(6-40)(7-28)(8-26)(9-21)(10-29)(11-31)(12-30)(13-23)(14-32)(15-27)(16-45)(17-25)(18-33)(19-34)(20-35)(21-22)(21-23)(22-37)(23-41)(24-31)(24-38)(25-31)(25-42)(26-28)(26-47)(27-36)(27-47)(28-46)(29-32)(29-39)(30-34)(30-40)(32-33)(33-43)(34-35)(35-44)(36-45)(36-46)(37-48)(38-49)(39-50)(40-51)(41-42)(41-48)(42-49)(43-44)(43-50)(44-51)(45-53)(46-52)(47-54)(48-55)(49-55)(50-55)(51-55)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 3.3 | — | 10.1039/d2dt00401a | 2022 |
| SW480 | 5.5 | — | 10.1039/d2dt00401a | 2022 |
| A549 | 7.9 | — | 10.1039/d2dt00401a | 2022 |
| HEK293 | 11 | — | 10.1039/d2dt00401a | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«"All complexes induce cell cycle arrest in G0/G1 and apoptosis" (Abstract) and "Anyway, all Ru(II) complexes induce apoptosis as a cell death mechanism in A549 cells" (Results, Apoptosis studies)»