Info
| ID | 4462 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 3, "O": 1, "P": 2} |
| Abbreviation | 2 |
| SMILES | CC#N.Cc1ccc([O-])c(/N=N/c2[c-]c3c(cc2)OCO3)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C52H43N3O3P2Ru/(1-50)(2-44)(3-44)(4-44)(5-49)(6-51)(7-53)(8-47)(9-54)(10-48)(11-52)(12-55)(13-63)(14-56)(15-59)(16-45)(17-81)(18-45)(19-45)(20-58)(21-61)(22-62)(23-65)(24-60)(25-64)(26-70)(27-73)(28-74)(29-66)(30-67)(31-69)(32-75)(33-76)(34-77)(35-80)(36-78)(37-79)(38-57)(39-89)(40-68)(41-71)(42-72)(43-89)(44-83)(45-82)(46-84)(46-88)(47-49)(47-50)(48-49)(48-51)(50-90)(51-90)(52-53)(52-54)(53-56)(54-91)(55-56)(55-91)(57-82)(57-85)(58-59)(58-63)(59-92)(60-61)(60-92)(61-63)(62-65)(62-66)(64-65)(64-67)(66-93)(67-93)(68-71)(68-84)(69-70)(69-94)(70-73)(71-87)(72-81)(72-86)(73-74)(74-75)(75-94)(76-77)(76-95)(77-80)(78-79)(78-80)(79-95)(81-82)(83-96)(84-97)(85-86)(85-98)(86-99)(87-88)(87-101)(88-100)(89-100)(89-101)(90-102)(91-102)(92-102)(93-103)(94-103)(95-103)(97-98)(97-104)(98-104)(100-104)(101-104)(102-104)(103-104)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 3.8 | — | 10.1021/acs.inorgchem.0c02563 | 2020 |
| HT-29 | 4.5 | — | 10.1021/acs.inorgchem.0c02563 | 2020 |
| NIH-3T3 | 7.2 | — | 10.1021/acs.inorgchem.0c02563 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«All three complexes induce cell death by apoptosis, as indicated by nuclear damage (fluorescence microscopy after staining with Hoechst dye).»