Info
| ID | 4461 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 2, "N": 2, "P": 2} |
| Abbreviation | 1 |
| SMILES | Cc1ccc([O-])c(/N=N/c2[c-]c3c(cc2)OCO3)c1.[C-]#[O+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C51H40N2O4P2Ru/(1-46)(2-44)(3-52)(4-45)(5-48)(6-43)(7-47)(8-49)(9-58)(10-50)(11-55)(12-41)(13-77)(14-74)(15-51)(16-76)(17-53)(18-54)(19-56)(20-57)(21-60)(22-61)(23-59)(24-66)(25-73)(26-67)(27-62)(28-41)(29-41)(30-63)(31-65)(32-68)(33-69)(34-70)(35-75)(36-71)(37-72)(38-64)(39-85)(40-85)(41-78)(42-80)(42-84)(43-44)(43-46)(44-86)(45-47)(45-86)(46-47)(48-50)(48-87)(49-53)(49-87)(50-52)(51-76)(51-78)(52-53)(54-55)(54-58)(55-88)(56-58)(56-61)(57-60)(57-62)(59-60)(59-63)(61-88)(62-89)(63-89)(64-78)(64-79)(65-66)(65-90)(66-73)(67-68)(67-73)(68-90)(69-70)(69-91)(70-75)(71-72)(71-75)(72-91)(74-77)(74-80)(76-83)(77-82)(79-83)(79-93)(80-92)(81-95)(82-84)(82-97)(83-94)(84-96)(85-96)(85-97)(86-98)(87-98)(88-98)(89-99)(90-99)(91-99)(92-93)(92-100)(93-100)(96-100)(97-100)(98-100)(99-100)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 4.2 | — | 10.1021/acs.inorgchem.0c02563 | 2020 |
| HT-29 | 4.3 | — | 10.1021/acs.inorgchem.0c02563 | 2020 |
| NIH-3T3 | 6.6 | — | 10.1021/acs.inorgchem.0c02563 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«All three complexes induce cell death by apoptosis, as indicated by nuclear damage (fluorescence microscopy after staining with Hoechst dye).»