Info
| ID | 4424 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 8 |
| SMILES | O=C(NC(=S)Nc1ccc2ccccc2c1)c1ccccc1.[Cl-].[Cl-].c1ccccc1 |
TUCAN
C24Cl2N2ORuS/(1-2)(1-4)(2-5)(3-6)(3-19)(4-17)(5-18)(6-14)(7-20)(7-22)(8-12)(8-16)(9-13)(9-19)(10-12)(10-21)(11-15)(11-22)(13-14)(15-21)(16-20)(17-18)(19-23)(20-21)(22-25)(23-26)(23-27)(24-25)(24-26)(24-28)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 10 | — | 10.1021/acsomega.9b00349 | 2019 |
| COLO-205 | 10 | — | 10.1021/acsomega.9b00349 | 2019 |
| IMR-32 | 10 | — | 10.1021/acsomega.9b00349 | 2019 |
| A549 | 11 | — | 10.1021/acsomega.9b00349 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cells treated with the complexes showed upregulated caspase-3 compared to the control, and it was found that ROS and MMP were dose-dependent on analysis. Also, bright-field microscopy and DAPI sta...»