Info
| ID | 4423 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 7 |
| SMILES | Cc1ccc(NC(=S)NC(=O)c2ccccc2)cc1.[Cl-].[Cl-].c1ccccc1 |
TUCAN
C21Cl2N2ORuS/(1-18)(2-6)(2-7)(3-4)(3-10)(4-12)(5-8)(5-19)(6-9)(7-13)(8-18)(9-14)(10-17)(11-12)(11-17)(13-14)(15-16)(15-18)(16-19)(17-20)(19-23)(20-22)(20-24)(21-22)(21-23)(21-25)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 8 | — | 10.1021/acsomega.9b00349 | 2019 |
| COLO-205 | 8 | — | 10.1021/acsomega.9b00349 | 2019 |
| A549 | 8 | — | 10.1021/acsomega.9b00349 | 2019 |
| IMR-32 | 8 | — | 10.1021/acsomega.9b00349 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cells treated with the complexes showed upregulated caspase-3 compared to the control, and it was found that ROS and MMP were dose-dependent on analysis. Also, bright-field microscopy and DAPI sta...»