Info
| ID | 4422 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 6 |
| SMILES | O=C(NC(=S)Nc1ccc2ccccc2c1)c1ccc(Cl)cc1Cl.[Cl-].[Cl-].c1ccccc1 |
TUCAN
C24Cl4N2ORuS/(1-2)(1-13)(2-14)(3-9)(3-23)(4-8)(4-10)(5-19)(5-20)(6-7)(6-20)(7-17)(8-11)(9-18)(10-17)(11-19)(12-23)(12-24)(13-15)(14-16)(15-16)(17-19)(18-21)(18-24)(20-25)(21-26)(21-27)(22-25)(22-26)(22-28)(23-31)(24-32)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| IMR-32 | 47 | — | 10.1021/acsomega.9b00349 | 2019 |
| MCF-7 | 55 | — | 10.1021/acsomega.9b00349 | 2019 |
| A549 | 59 | — | 10.1021/acsomega.9b00349 | 2019 |
| COLO-205 | 62 | — | 10.1021/acsomega.9b00349 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cells treated with the complexes showed upregulated caspase-3 compared to the control, and it was found that ROS and MMP were dose-dependent on analysis. Also, bright-field microscopy and DAPI sta...»