Info
| ID | 4421 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 5 |
| SMILES | O=C(NC(=S)Nc1ccccc1)c1ccc(Cl)cc1Cl.[Cl-].[Cl-].c1ccccc1 |
TUCAN
C20Cl4N2ORuS/(1-2)(1-11)(2-12)(3-7)(3-19)(4-5)(4-6)(5-16)(6-8)(7-15)(8-9)(9-16)(10-19)(10-20)(11-13)(12-14)(13-14)(15-17)(15-20)(16-21)(17-22)(17-23)(18-21)(18-22)(18-24)(19-27)(20-28)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| COLO-205 | 8 | — | 10.1021/acsomega.9b00349 | 2019 |
| IMR-32 | 8 | — | 10.1021/acsomega.9b00349 | 2019 |
| MCF-7 | 9 | — | 10.1021/acsomega.9b00349 | 2019 |
| A549 | 9 | — | 10.1021/acsomega.9b00349 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cells treated with the complexes showed upregulated caspase-3 compared to the control, and it was found that ROS and MMP were dose-dependent on analysis. Also, bright-field microscopy and DAPI sta...»