Info
| ID | 4420 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 4 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(NC(=S)Nc1ccc2ccccc2c1)c1ccccc1.[Cl-].[Cl-] |
TUCAN
C28Cl2N2ORuS/(1-21)(2-25)(3-25)(4-16)(4-20)(5-13)(5-24)(6-12)(6-20)(7-9)(7-10)(8-23)(8-26)(9-11)(10-19)(11-22)(12-15)(13-21)(14-18)(14-24)(15-17)(16-26)(17-23)(18-21)(19-22)(20-23)(22-27)(24-25)(26-30)(27-29)(27-31)(28-29)(28-30)(28-32)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| COLO-205 | 11 | — | 10.1021/acsomega.9b00349 | 2019 |
| IMR-32 | 46 | — | 10.1021/acsomega.9b00349 | 2019 |
| MCF-7 | 55 | — | 10.1021/acsomega.9b00349 | 2019 |
| A549 | 58 | — | 10.1021/acsomega.9b00349 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cells treated with the complexes showed upregulated caspase-3 compared to the control, and it was found that ROS and MMP were dose-dependent on analysis. Also, bright-field microscopy and DAPI sta...»