Info
| ID | 4418 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 2 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(NC(=S)Nc1ccc2ccccc2c1)c1ccc(Cl)cc1Cl.[Cl-].[Cl-] |
TUCAN
C28Cl4N2ORuS/(1-19)(2-18)(3-18)(4-7)(4-19)(5-6)(5-22)(6-24)(7-20)(8-11)(8-21)(9-10)(9-27)(10-23)(11-15)(12-13)(12-19)(13-20)(14-15)(14-22)(16-21)(16-24)(17-27)(17-28)(18-20)(21-22)(23-25)(23-28)(24-30)(25-29)(25-31)(26-29)(26-30)(26-32)(27-35)(28-36)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| IMR-32 | 34 | — | 10.1021/acsomega.9b00349 | 2019 |
| COLO-205 | 38 | — | 10.1021/acsomega.9b00349 | 2019 |
| MCF-7 | 41 | — | 10.1021/acsomega.9b00349 | 2019 |
| A549 | 43 | — | 10.1021/acsomega.9b00349 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cells treated with the complexes showed upregulated caspase-3 compared to the control, and it was found that ROS and MMP were dose-dependent on analysis. Also, bright-field microscopy and DAPI sta...»