Info
| ID | 4417 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 1 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(NC(=S)Nc1ccccc1)c1ccc(Cl)cc1Cl.[Cl-].[Cl-] |
TUCAN
C24Cl4N2ORuS/(1-17)(2-16)(3-17)(4-10)(4-18)(5-7)(5-9)(6-8)(6-23)(7-12)(8-19)(9-14)(10-16)(11-13)(11-18)(12-20)(13-16)(14-20)(15-23)(15-24)(17-18)(19-21)(19-24)(20-25)(21-26)(21-27)(22-25)(22-26)(22-28)(23-31)(24-32)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| IMR-32 | 14 | — | 10.1021/acsomega.9b00349 | 2019 |
| COLO-205 | 17 | — | 10.1021/acsomega.9b00349 | 2019 |
| MCF-7 | 18 | — | 10.1021/acsomega.9b00349 | 2019 |
| A549 | 22 | — | 10.1021/acsomega.9b00349 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cells treated with the complexes showed upregulated caspase-3 compared to the control, and it was found that ROS and MMP were dose-dependent on analysis. Also, bright-field microscopy and DAPI sta...»