Info
| ID | 4359 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | RuZ |
| SMILES | [c-]1cccc2ccc3cccnc3c12.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C43H26N7Ru/(1-35)(2-56)(3-38)(4-44)(5-40)(6-34)(7-58)(8-36)(9-42)(10-39)(11-59)(12-46)(13-28)(14-48)(15-32)(16-31)(17-60)(18-29)(19-47)(20-33)(21-37)(22-45)(23-57)(24-43)(25-30)(26-41)(27-29)(27-53)(28-36)(28-52)(29-40)(30-31)(30-50)(31-55)(32-47)(32-60)(33-42)(33-46)(34-35)(34-49)(35-56)(36-58)(37-43)(37-59)(38-39)(38-52)(39-54)(40-41)(41-50)(42-48)(43-54)(44-45)(44-51)(45-57)(46-63)(47-55)(48-69)(49-61)(49-62)(50-53)(51-64)(51-68)(52-65)(53-66)(54-67)(55-66)(56-73)(57-71)(58-74)(59-75)(60-76)(61-64)(61-72)(62-68)(62-73)(63-69)(63-70)(64-70)(65-67)(65-74)(66-76)(67-75)(68-71)(69-72)(72-77)(73-77)(74-77)(75-77)(76-77)
Measurements (13)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 0.67 | — | 10.1002/adma.202100245 | 2021 |
| H460/MX20 | 0.7 | — | 10.1002/adma.202100245 | 2021 |
| BIU-87 | 0.85 | — | 10.1002/adma.202100245 | 2021 |
| SW620 | 0.97 | — | 10.1002/adma.202100245 | 2021 |
| MDA-MB-231 | 1.2 | — | 10.1002/adma.202100245 | 2021 |
| BIU-87/DDP | 1.3 | — | 10.1002/adma.202100245 | 2021 |
| BEL-7404/CP20 | 1.3 | — | 10.1002/adma.202100245 | 2021 |
| BEL-7404 | 1.4 | — | 10.1002/adma.202100245 | 2021 |
| KB/ATO | 1.6 | — | 10.1002/adma.202100245 | 2021 |
| SW620/AD300 | 1.8 | — | 10.1002/adma.202100245 | 2021 |
| KB-3-1 | 1.8 | — | 10.1002/adma.202100245 | 2021 |
| MDA-MB-231/Adr | 2 | — | 10.1002/adma.202100245 | 2021 |
| KB-C2 | 2.6 | — | 10.1002/adma.202100245 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«RuZ, after 24 h of incubation, produced a concentration-dependent increase in apoptosis, as determined using the calcein AM/PI assay, in MDA-MB-231/Adr cells (Figure 4A, B). Furthermore, 2.5 × 10−6 m ...»