Info
| ID | 4319 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"S": 1, "N": 3} |
| Abbreviation | RuBCAC |
| SMILES | [Cl-].[S-]/C(=N\N=C/C=C/c1ccccc1)Nc1ccccc1.c1ccccc1 |
TUCAN
C22H20N3RuS/(1-21)(2-22)(3-23)(4-24)(5-28)(6-33)(7-29)(8-27)(9-25)(10-26)(11-34)(12-31)(13-37)(14-36)(15-35)(16-30)(17-40)(18-38)(19-32)(20-43)(21-22)(21-23)(22-24)(23-25)(24-26)(25-26)(27-28)(27-34)(28-41)(29-31)(29-36)(30-38)(30-39)(31-39)(32-35)(32-39)(33-37)(33-41)(34-37)(35-36)(38-40)(40-45)(41-43)(42-43)(42-44)(42-46)(44-45)(44-47)(45-47)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 52 | — | 10.1021/acsabm.4c00689 | 2024 |
| MDA-MB-231 | 86 | — | 10.1021/acsabm.4c00689 | 2024 |
| HeLa | 91 | — | 10.1021/acsabm.4c00689 | 2024 |
| MCF-10A | — | — | 10.1021/acsabm.4c00689 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«The active complexes were found to trigger apoptosis, a vital cellular process crucial for evaluating their potential as anticancer agents utilizing staining assays and flow cytometry analysis.»