Info
| ID | 4305 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 6} |
| Abbreviation | 2 |
| SMILES | COc1cc(/C=C/C(=O)/C=C([O-])/C=C/c2ccc(OCCN3CCOCC3)c(OC)c2)ccc1OCCN1CCOCC1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C53H57N6O8Ru/(1-58)(2-83)(3-101)(4-101)(5-103)(6-90)(7-63)(8-102)(9-59)(10-100)(11-103)(12-102)(13-88)(14-87)(15-84)(16-85)(17-86)(18-61)(19-62)(20-60)(21-74)(22-87)(23-104)(24-90)(25-66)(26-75)(27-64)(28-65)(29-67)(30-98)(31-98)(32-91)(33-99)(34-99)(35-69)(36-77)(37-79)(38-80)(39-78)(40-70)(41-68)(42-76)(43-98)(44-97)(45-104)(46-100)(47-71)(48-88)(49-97)(50-97)(51-92)(52-72)(53-73)(54-91)(55-92)(56-89)(57-89)(58-59)(58-60)(59-83)(60-93)(61-63)(61-84)(62-66)(62-85)(63-64)(64-94)(65-66)(65-95)(67-75)(67-96)(68-70)(68-81)(69-77)(69-105)(70-106)(71-72)(71-107)(72-81)(73-82)(73-108)(74-75)(74-86)(76-81)(76-110)(77-82)(78-106)(78-109)(79-80)(79-82)(80-109)(83-113)(84-114)(85-115)(86-116)(87-101)(87-112)(88-103)(88-111)(89-102)(89-112)(90-100)(90-112)(91-99)(91-111)(92-104)(92-111)(93-94)(93-113)(94-114)(95-96)(95-115)(96-116)(97-121)(98-123)(99-122)(100-119)(101-120)(102-120)(103-124)(104-124)(105-108)(105-122)(106-118)(107-110)(107-119)(108-121)(109-117)(110-123)(113-125)(114-125)(115-125)(116-125)(122-125)(123-125)(124-125)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MIA PaCa-2 | 0.3 | — | 10.1002/chem.202403695 | 2025 |
| MIA PaCa-2 | 0.38 | 0.24 | 10.1002/chem.202403695 | 2025 |
| MDA-MB-231 | 0.43 | — | 10.1002/chem.202403695 | 2025 |
| MDA-MB-231 | 0.62 | 0.28 | 10.1002/chem.202403695 | 2025 |
| PANC-1 | 1.1 | — | 10.1002/chem.202403695 | 2025 |
| PANC-1 | 1.1 | 0.73 | 10.1002/chem.202403695 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 2 induces apoptosis via the intrinsic pathway»
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