Info
| ID | 4286 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3} |
| Abbreviation | 2 |
| SMILES | Cc1ccc(C(C)C)cc1.Cc1cccc(C)c1/N=C/c1ncc[nH]1.[Cl-] |
TUCAN
C22H27N3Ru/(1-28)(2-28)(3-33)(4-30)(5-30)(6-37)(7-38)(8-34)(9-29)(10-29)(11-29)(12-30)(13-31)(14-36)(15-28)(16-32)(17-47)(18-32)(19-46)(20-32)(21-39)(22-45)(23-31)(24-44)(25-31)(26-35)(27-50)(28-41)(29-40)(30-44)(31-44)(32-43)(33-36)(33-39)(34-37)(34-40)(35-38)(35-40)(36-41)(37-42)(38-42)(39-43)(41-48)(42-44)(43-48)(45-47)(45-51)(46-49)(46-52)(47-50)(48-52)(49-50)(49-51)(51-53)(52-53)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 7 | — | 10.1039/c5dt04781a | 2016 |
| HepG2 | 10 | — | 10.1039/c5dt04781a | 2016 |
| HFF-1 | 10 | — | 10.1039/c5dt04781a | 2016 |
| NIH-3T3 | 11 | — | 10.1039/c5dt04781a | 2016 |
| MIA PaCa-2 | 12 | — | 10.1039/c5dt04781a | 2016 |
| A549 | 19 | — | 10.1039/c5dt04781a | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cellular studies show that all the three complexes ... induce cellular death through caspase activation via the mitochondrial pathway.»