Info
| ID | 4247 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3} |
| Abbreviation | 6 |
| SMILES | COC(=O)c1cc(/N=C/c2ncc[nH]2)ccc1O.Cc1ccc(C(C)C)cc1.[I-] |
TUCAN
C22H25N3O3Ru/(1-39)(2-33)(3-26)(4-26)(5-34)(6-26)(7-27)(8-29)(9-28)(10-27)(11-27)(12-28)(13-28)(14-30)(15-41)(16-35)(17-45)(18-45)(19-45)(20-42)(21-40)(22-32)(23-31)(24-48)(25-52)(26-39)(27-37)(28-39)(29-33)(29-36)(30-34)(30-36)(31-32)(31-43)(32-46)(33-37)(34-37)(35-38)(35-43)(36-39)(38-46)(38-47)(40-42)(40-48)(41-44)(41-50)(42-49)(43-50)(44-48)(44-49)(45-53)(46-52)(47-51)(47-53)(49-54)(50-54)(53-54)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 2.2 | — | 10.1039/d0cc00472c | 2020 |
| MIA PaCa-2 | 2.3 | — | 10.1039/d0cc00472c | 2020 |
| HepG2 | 2.4 | — | 10.1039/d0cc00472c | 2020 |
| HT-29 | 2.6 | — | 10.1039/d0cc00472c | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«The levels of active caspase-3 and cleaved PARP (Asp214) were increased in RCT-treated HepG2 cells, indicating the induction of apoptotic cell death.»
Autophagy
high
«RCT modulated the autophagy markers LC3B and p62/SQSTM1 in HepG2 cells and increased mitophagy in a mt-Keima-transfected mouse embryonic fibroblast (MEF) cell model, and RCT-induced cytotoxicity was p...»