Info
| ID | 4245 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3} |
| Abbreviation | 4 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(O)c1cc(/N=C/c2ncc[nH]2)ccc1O.[Cl-] |
TUCAN
C21H23N3O3Ru/(1-28)(2-24)(3-24)(4-25)(5-24)(6-33)(7-40)(8-39)(9-38)(10-27)(11-32)(12-29)(13-30)(14-25)(15-25)(16-26)(17-26)(18-31)(19-37)(20-26)(21-45)(22-49)(23-50)(24-35)(25-37)(26-37)(27-34)(27-41)(28-29)(28-35)(29-36)(30-31)(30-36)(31-35)(32-33)(32-43)(33-41)(34-43)(34-44)(36-37)(38-39)(38-46)(39-45)(40-42)(40-47)(41-47)(42-45)(42-46)(43-49)(44-48)(44-50)(46-51)(47-51)(50-51)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HT-29 | — | — | 10.1039/d0cc00472c | 2020 |
| MIA PaCa-2 | — | — | 10.1039/d0cc00472c | 2020 |
| HepG2 | — | — | 10.1039/d0cc00472c | 2020 |
| MDA-MB-231 | — | — | 10.1039/d0cc00472c | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«The levels of active caspase-3 and cleaved PARP (Asp214) were increased in RCT-treated HepG2 cells, indicating the induction of apoptotic cell death.»
Autophagy
high
«RCT modulated the autophagy markers LC3B and p62/SQSTM1 in HepG2 cells and increased mitophagy in a mt-Keima-transfected mouse embryonic fibroblast (MEF) cell model, and RCT-induced cytotoxicity was p...»