Info
| ID | 4244 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 3 |
| SMILES | COC(=O)c1cc(/N=C/c2ccccn2)ccc1O.Cc1ccc(C(C)C)cc1.[I-] |
TUCAN
C24H26N2O3Ru/(1-27)(2-34)(3-27)(4-27)(5-29)(6-30)(7-28)(8-35)(9-43)(10-31)(11-29)(12-28)(13-28)(14-33)(15-39)(16-45)(17-37)(18-48)(19-48)(20-36)(21-38)(22-29)(23-32)(24-44)(25-48)(26-54)(27-43)(28-43)(29-41)(30-34)(30-40)(31-32)(31-49)(32-47)(33-35)(33-40)(34-41)(35-41)(36-38)(36-39)(37-42)(37-47)(38-44)(39-46)(40-43)(42-49)(42-50)(44-51)(45-46)(45-52)(46-51)(47-52)(48-55)(49-54)(50-53)(50-55)(51-56)(52-56)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 42 | — | 10.1039/d0cc00472c | 2020 |
| HepG2 | 51 | — | 10.1039/d0cc00472c | 2020 |
| MIA PaCa-2 | 54 | — | 10.1039/d0cc00472c | 2020 |
| HT-29 | 56 | — | 10.1039/d0cc00472c | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«The levels of active caspase-3 and cleaved PARP (Asp214) were increased in RCT-treated HepG2 cells, indicating the induction of apoptotic cell death.»
Autophagy
high
«RCT modulated the autophagy markers LC3B and p62/SQSTM1 in HepG2 cells and increased mitophagy in a mt-Keima-transfected mouse embryonic fibroblast (MEF) cell model, and RCT-induced cytotoxicity was p...»