Info
| ID | 4242 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 1 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(O)c1cc(/N=C/c2ccccn2)ccc1O.[Cl-] |
TUCAN
C23H24N2O3Ru/(1-25)(2-30)(3-26)(4-25)(5-25)(6-28)(7-35)(8-29)(9-34)(10-42)(11-43)(12-36)(13-33)(14-37)(15-26)(16-26)(17-27)(18-31)(19-27)(20-41)(21-27)(22-32)(23-52)(24-51)(25-38)(26-41)(27-41)(28-33)(28-44)(29-40)(29-44)(30-31)(30-38)(31-39)(32-37)(32-39)(33-46)(34-35)(34-43)(35-36)(36-45)(37-38)(39-41)(40-46)(40-47)(42-45)(42-49)(43-48)(44-49)(45-48)(46-52)(47-50)(47-51)(48-53)(49-53)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HT-29 | — | — | 10.1039/d0cc00472c | 2020 |
| MIA PaCa-2 | — | — | 10.1039/d0cc00472c | 2020 |
| HepG2 | — | — | 10.1039/d0cc00472c | 2020 |
| MDA-MB-231 | — | — | 10.1039/d0cc00472c | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«The levels of active caspase-3 and cleaved PARP (Asp214) were increased in RCT-treated HepG2 cells, indicating the induction of apoptotic cell death.»
Autophagy
high
«RCT modulated the autophagy markers LC3B and p62/SQSTM1 in HepG2 cells and increased mitophagy in a mt-Keima-transfected mouse embryonic fibroblast (MEF) cell model, and RCT-induced cytotoxicity was p...»