Info
| ID | 4221 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1} |
| Abbreviation | 1b |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[O-]n1c(=S)ccc2ccccc21 |
TUCAN
C19ClNORuS/(1-14)(2-15)(3-14)(4-7)(4-18)(5-6)(5-7)(6-17)(8-10)(8-15)(9-13)(9-19)(10-16)(11-12)(11-15)(12-16)(13-17)(14-16)(17-18)(18-20)(19-20)(19-22)(20-21)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 2.2 | — | 10.3390/cancers13102493 | 2021 |
| A2780cisR | 2.5 | — | 10.3390/cancers13102493 | 2021 |
| SW626 | 2.8 | — | 10.3390/cancers13102493 | 2021 |
| A2780/ADR | 2.8 | — | 10.3390/cancers13102493 | 2021 |
| PC-3 | 3.9 | — | 10.3390/cancers13102493 | 2021 |
| SK-OV-3 | 5.1 | — | 10.3390/cancers13102493 | 2021 |
| A549 | 5.8 | — | 10.3390/cancers13102493 | 2021 |
| HCT-116 | 8.4 | — | 10.3390/cancers13102493 | 2021 |
| OE19 | 11 | — | 10.3390/cancers13102493 | 2021 |
| HepG2 | 26 | — | 10.3390/cancers13102493 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
medium
«A2780 cells treated with complex 1a only showed partial evidence for apoptotic cell death (8.4% of cell population)»