Info
| ID | 4216 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 4 |
| SMILES | CC(C)c1cc(C(C)C)cc(C(C)C)c1.CC(C)c1ccc(/N=C/c2ccc3ccccc3n2)cc1.[Cl-] |
TUCAN
C34H42N2Ru/(1-60)(2-43)(3-43)(4-51)(5-43)(6-73)(7-70)(8-54)(9-44)(10-44)(11-44)(12-71)(13-72)(14-45)(15-45)(16-45)(17-46)(18-55)(19-63)(20-52)(21-69)(22-50)(23-57)(24-53)(25-62)(26-58)(27-50)(28-56)(29-50)(30-59)(31-61)(32-46)(33-46)(34-47)(35-47)(36-47)(37-48)(38-48)(39-48)(40-49)(41-49)(42-49)(43-69)(44-70)(45-70)(46-71)(47-71)(48-72)(49-72)(50-69)(51-60)(51-74)(52-56)(52-76)(53-61)(53-76)(54-64)(54-67)(55-64)(55-68)(56-65)(57-59)(57-62)(58-59)(58-75)(60-66)(61-65)(62-66)(63-67)(63-68)(64-70)(65-69)(66-75)(67-71)(68-72)(73-74)(73-77)(74-78)(75-78)(76-77)(77-79)(78-79)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 p53-/- | 0.34 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| A2780 | 0.35 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HT-29 | 0.38 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| AGS | 0.45 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| A2780cisR | 0.46 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HCT-116 | 0.47 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| TC7 | 1 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
🧬 Cell Death Types (1)
Apoptosis
low
«The article does not explicitly state that the complexes induce apoptosis; it focuses on ER stress and non-apoptotic cell death. However, the introduction mentions that ER stress can lead to apoptosis...»