Info
| ID | 4215 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3} |
| Abbreviation | 3 |
| SMILES | CC(C)c1cc(C(C)C)cc(C(C)C)c1.CN(C)c1ccc(/N=C/c2ccc3ccccc3n2)cc1.[Cl-] |
TUCAN
C33H41N3Ru/(1-50)(2-68)(3-68)(4-68)(5-69)(6-69)(7-42)(8-42)(9-42)(10-43)(11-65)(12-43)(13-43)(14-66)(15-52)(16-70)(17-55)(18-49)(19-57)(20-51)(21-59)(22-58)(23-60)(24-69)(25-48)(26-56)(27-53)(28-44)(29-44)(30-44)(31-45)(32-45)(33-45)(34-54)(35-46)(36-46)(37-67)(38-46)(39-47)(40-47)(41-47)(42-65)(43-65)(44-66)(45-66)(46-67)(47-67)(48-51)(48-60)(49-50)(49-71)(50-72)(51-61)(52-62)(52-63)(53-62)(53-64)(54-63)(54-64)(55-60)(55-74)(56-59)(56-72)(57-58)(57-61)(58-73)(59-71)(61-74)(62-65)(63-66)(64-67)(68-75)(69-75)(70-73)(70-76)(71-76)(72-75)(73-77)(74-77)(76-78)(77-78)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 p53-/- | 0.27 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| A2780 | 0.29 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| AGS | 0.38 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HT-29 | 0.39 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| A2780cisR | 0.43 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HCT-116 | 0.46 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| TC7 | 1.6 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
🧬 Cell Death Types (1)
Apoptosis
low
«The article does not explicitly state that the complexes induce apoptosis; it focuses on ER stress and non-apoptotic cell death. However, the introduction mentions that ER stress can lead to apoptosis...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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