Info
| ID | 4214 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 2 |
| SMILES | CC(C)c1cc(C(C)C)cc(C(C)C)c1.CCc1ccc(/N=C/c2ccc3ccccc3n2)cc1.[Cl-] |
TUCAN
C33H40N2Ru/(1-60)(2-50)(3-61)(4-58)(5-61)(6-70)(7-41)(8-41)(9-67)(10-52)(11-41)(12-42)(13-42)(14-42)(15-43)(16-43)(17-43)(18-44)(19-47)(20-47)(21-56)(22-48)(23-57)(24-51)(25-47)(26-55)(27-49)(28-59)(29-44)(30-44)(31-45)(32-68)(33-45)(34-45)(35-46)(36-46)(37-53)(38-46)(39-54)(40-69)(41-67)(42-67)(43-68)(44-68)(45-69)(46-69)(47-61)(48-50)(48-72)(49-51)(49-56)(50-62)(51-71)(52-63)(52-64)(53-63)(53-65)(54-64)(54-65)(55-59)(55-72)(56-57)(57-66)(58-60)(58-73)(59-62)(60-66)(61-62)(63-67)(64-68)(65-69)(66-71)(70-73)(70-74)(71-75)(72-74)(73-75)(74-76)(75-76)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.37 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HCT-116 p53-/- | 0.39 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HT-29 | 0.42 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| A2780cisR | 0.49 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HCT-116 | 0.53 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| AGS | 0.54 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| TC7 | 1.4 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
🧬 Cell Death Types (1)
Apoptosis
low
«The article does not explicitly state that the complexes induce apoptosis; it focuses on ER stress and non-apoptotic cell death. However, the introduction mentions that ER stress can lead to apoptosis...»