Info
| ID | 420 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1} |
| Abbreviation | RANHC-VI |
| SMILES | COC(Cn1[c-][n+](C)c2ccccc21)c1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C27Cl2N2ORu/(1-19)(2-18)(3-18)(4-7)(4-17)(5-16)(5-17)(6-8)(6-20)(7-19)(8-13)(9-10)(9-23)(10-12)(11-14)(11-20)(12-15)(13-14)(15-24)(16-19)(17-18)(20-27)(21-28)(22-27)(22-29)(23-24)(23-29)(24-28)(25-28)(25-29)(26-30)(27-30)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BALB/3T3 | 39 | — | 10.3390/antibiotics12040693 | 2023 |
| MDA-MB-231 | 41 | — | 10.3390/antibiotics12040693 | 2023 |
| MCF-7 | 55 | — | 10.3390/antibiotics12040693 | 2023 |
| SH-SY5Y | 67 | — | 10.3390/antibiotics12040693 | 2023 |
| MCF-10A | 91 | — | 10.3390/antibiotics12040693 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Thus, using the TUNEL assay we determined whether the Ru-NHC complexes RANHC-V and -VI were able to trigger apoptosis in the MDA-MB-231 cells. ... the breast cancer cells treated with complexes RANHC-...»