Info
| ID | 419 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1} |
| Abbreviation | RANHC-V |
| SMILES | COC(Cn1[c-][n+](C)c(Cl)c1Cl)c1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C23Cl4N2ORu/(1-13)(2-14)(3-14)(4-5)(4-6)(5-16)(6-10)(7-9)(7-13)(8-12)(8-13)(9-15)(10-11)(11-16)(12-15)(14-15)(16-21)(17-25)(18-21)(18-24)(19-24)(19-25)(20-26)(21-26)(22-23)(22-24)(22-30)(23-25)(23-29)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 24 | — | 10.3390/antibiotics12040693 | 2023 |
| MCF-7 | 26 | — | 10.3390/antibiotics12040693 | 2023 |
| SH-SY5Y | 48 | — | 10.3390/antibiotics12040693 | 2023 |
| MCF-10A | 79 | — | 10.3390/antibiotics12040693 | 2023 |
| BALB/3T3 | — | — | 10.3390/antibiotics12040693 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Thus, using the TUNEL assay we determined whether the Ru-NHC complexes RANHC-V and -VI were able to trigger apoptosis in the MDA-MB-231 cells. ... the breast cancer cells treated with complexes RANHC-...»