Info
| ID | 418 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1, "O": 2} |
| Abbreviation | RANHC-IV |
| SMILES | COC(Cn1[c-][n+](C)cc1)c1ccccc1.Cc1ccc(C(C)C)cc1.O=C([O-])C(=O)[O-] |
TUCAN
C25N2O5Ru/(1-15)(2-14)(3-14)(4-6)(4-15)(5-7)(5-15)(6-13)(7-13)(8-9)(8-16)(9-11)(10-12)(10-16)(11-12)(13-14)(16-23)(17-27)(18-23)(18-26)(19-20)(19-26)(20-27)(21-26)(21-27)(22-32)(23-32)(24-25)(24-28)(24-29)(25-30)(25-31)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SH-SY5Y | 89 | — | 10.3390/antibiotics12040693 | 2023 |
| MDA-MB-231 | — | — | 10.3390/antibiotics12040693 | 2023 |
| MCF-7 | — | — | 10.3390/antibiotics12040693 | 2023 |
| MCF-10A | — | — | 10.3390/antibiotics12040693 | 2023 |
| BALB/3T3 | — | — | 10.3390/antibiotics12040693 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Thus, using the TUNEL assay we determined whether the Ru-NHC complexes RANHC-V and -VI were able to trigger apoptosis in the MDA-MB-231 cells. ... the breast cancer cells treated with complexes RANHC-...»