Info
| ID | 415 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1} |
| Abbreviation | RANHC-I |
| SMILES | COC(Cn1[c-][n+](C)cc1)c1ccccc1.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C23Cl2N2ORu/(1-14)(2-14)(3-15)(4-5)(4-13)(5-15)(6-12)(6-13)(7-8)(7-16)(8-10)(9-11)(9-16)(10-11)(12-15)(13-14)(16-23)(17-25)(18-23)(18-24)(19-20)(19-24)(20-25)(21-24)(21-25)(22-26)(23-26)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SH-SY5Y | 90 | — | 10.3390/antibiotics12040693 | 2023 |
| MDA-MB-231 | — | — | 10.3390/antibiotics12040693 | 2023 |
| MCF-7 | — | — | 10.3390/antibiotics12040693 | 2023 |
| MCF-10A | — | — | 10.3390/antibiotics12040693 | 2023 |
| BALB/3T3 | — | — | 10.3390/antibiotics12040693 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Thus, using the TUNEL assay we determined whether the Ru-NHC complexes RANHC-V and -VI were able to trigger apoptosis in the MDA-MB-231 cells. ... the breast cancer cells treated with complexes RANHC-...»