Info
| ID | 4114 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1} |
| Abbreviation | 3 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(/C=C(\[O-])C(F)(F)F)c1ccccc1.[Cl-] |
TUCAN
C20ClF3O2Ru/(1-15)(2-14)(3-15)(4-18)(4-19)(5-10)(5-17)(6-7)(6-16)(7-8)(8-9)(9-13)(10-14)(11-12)(11-17)(12-14)(13-16)(15-17)(16-19)(18-20)(18-21)(19-22)(20-23)(20-24)(20-25)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 21 | — | 10.1021/acs.jmedchem.2c01174 | 2022 |
| A2780cisR | 26 | — | 10.1021/acs.jmedchem.2c01174 | 2022 |
| HeLa | 30 | — | 10.1021/acs.jmedchem.2c01174 | 2022 |
🧬 Cell Death Types (1)
Necroptosis
high
«Western blot analysis confirmed that similar to a known necroptosis-inducer shikonin, treatment with 1 increased the expression level of RIP1 and RIP3 in HeLa cells (Figure 12c), confirming necroptosi...»