Info
| ID | 4112 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 5} |
| Abbreviation | [Ru(phen)2(hbtz)][PF6] (4) |
| SMILES | [O-]c1ccccc1-c1nc2ccccc2s1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C37H24N5ORuS/(1-25)(2-29)(3-30)(4-35)(5-31)(6-36)(7-50)(8-43)(9-28)(10-42)(11-39)(12-32)(13-51)(14-41)(15-26)(16-44)(17-27)(18-33)(19-40)(20-52)(21-34)(22-53)(23-38)(24-37)(25-35)(25-50)(26-28)(26-59)(27-38)(27-44)(28-43)(29-31)(29-46)(30-39)(30-51)(31-47)(32-41)(32-48)(33-40)(33-52)(34-36)(34-53)(35-46)(36-47)(37-38)(37-58)(39-48)(40-49)(41-49)(42-43)(42-45)(44-60)(45-59)(45-61)(46-54)(47-55)(48-56)(49-57)(50-62)(51-63)(52-64)(53-65)(54-55)(54-62)(55-65)(56-57)(56-63)(57-64)(58-60)(58-66)(59-67)(60-68)(61-66)(61-68)(62-69)(63-69)(64-69)(65-69)(66-69)(68-69)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.8 | — | 10.1021/acs.inorgchem.8b01988 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«An investigation of the mechanism of cell death led to the finding that compounds 1−4 disrupt the mitochondrial transmembrane potential (ΔΨm) in a concentration-dependent fashion, which is an event as...»