Info
| ID | 4110 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 6} |
| Abbreviation | [Ru(phen)2(dphol)][PF6] (2) |
| SMILES | [O-]c1cccc2nc3c4ccccc4c4ccccc4c3nc12.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C44H27N6ORu/(1-59)(2-29)(3-60)(4-35)(5-37)(6-30)(7-48)(8-41)(9-50)(10-36)(11-28)(12-47)(13-49)(14-32)(15-44)(16-38)(17-61)(18-45)(19-39)(20-42)(21-31)(22-40)(23-43)(24-46)(25-62)(26-34)(27-33)(28-38)(28-51)(29-30)(29-59)(30-51)(31-34)(31-65)(32-35)(32-54)(33-34)(33-71)(35-50)(36-45)(36-52)(37-40)(37-60)(38-52)(39-46)(39-56)(40-56)(41-42)(41-49)(42-58)(43-44)(43-57)(44-61)(45-62)(46-57)(47-50)(47-55)(48-49)(48-53)(51-63)(52-66)(53-54)(53-58)(54-55)(55-68)(56-67)(57-69)(58-70)(59-72)(60-75)(61-76)(62-77)(63-66)(63-72)(64-65)(64-71)(64-73)(65-74)(66-77)(67-69)(67-75)(68-70)(68-73)(69-76)(70-74)(71-78)(72-79)(73-79)(74-79)(75-79)(76-79)(77-79)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 1.3 | — | 10.1021/acs.inorgchem.8b01988 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«An investigation of the mechanism of cell death led to the finding that compounds 1−4 disrupt the mitochondrial transmembrane potential (ΔΨm) in a concentration-dependent fashion, which is an event as...»