Info
| ID | 4109 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 6} |
| Abbreviation | [Ru(bpy)2(dphol)][PF6] (1) |
| SMILES | [O-]c1cccc2nc3c4ccccc4c4ccccc4c3nc12.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C40H27N6ORu/(1-55)(2-37)(3-29)(4-30)(5-38)(6-56)(7-36)(8-34)(9-28)(10-43)(11-31)(12-41)(13-57)(14-58)(15-39)(16-46)(17-48)(18-40)(19-45)(20-50)(21-33)(22-49)(23-42)(24-47)(25-44)(26-32)(27-35)(28-29)(28-37)(29-59)(30-39)(30-60)(31-34)(31-36)(32-35)(32-67)(33-34)(33-51)(35-50)(36-54)(37-55)(38-39)(38-56)(40-45)(40-62)(41-42)(41-53)(42-49)(43-45)(43-57)(44-47)(44-65)(46-47)(46-58)(48-49)(48-52)(50-66)(51-54)(51-63)(52-53)(52-64)(53-54)(55-68)(56-69)(57-71)(58-73)(59-60)(59-68)(60-69)(61-66)(61-67)(61-70)(62-65)(62-71)(63-64)(63-72)(64-70)(65-73)(66-72)(67-74)(68-75)(69-75)(70-75)(71-75)(72-75)(73-75)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 6.6 | — | 10.1021/acs.inorgchem.8b01988 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«An investigation of the mechanism of cell death led to the finding that compounds 1−4 disrupt the mitochondrial transmembrane potential (ΔΨm) in a concentration-dependent fashion, which is an event as...»