Info
| ID | 4074 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 1 |
| SMILES | CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1.CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C56H44F8N8O8RuS2/(1-79)(2-48)(3-47)(4-61)(5-45)(6-97)(7-51)(8-50)(9-56)(10-54)(11-52)(12-45)(13-59)(14-80)(15-63)(16-62)(17-45)(18-97)(19-55)(20-46)(21-57)(22-65)(23-64)(24-49)(25-60)(26-66)(27-46)(28-46)(29-71)(30-68)(31-58)(32-98)(33-67)(34-53)(35-70)(36-69)(37-81)(38-82)(39-72)(40-98)(41-103)(42-104)(43-115)(44-116)(45-89)(46-90)(47-48)(47-79)(48-51)(49-74)(49-85)(50-56)(50-80)(51-83)(52-60)(52-99)(53-75)(53-88)(54-56)(54-84)(55-62)(55-86)(57-65)(57-87)(58-66)(58-99)(59-61)(59-73)(60-93)(61-85)(62-63)(63-81)(64-65)(64-82)(66-93)(67-68)(67-100)(68-94)(69-72)(69-100)(70-71)(70-76)(71-88)(72-94)(73-74)(73-77)(74-95)(75-76)(75-96)(76-78)(77-101)(78-102)(79-105)(80-106)(81-107)(82-108)(83-84)(83-105)(84-106)(85-103)(86-87)(86-107)(87-108)(88-104)(89-91)(89-97)(89-115)(90-92)(90-98)(90-116)(91-103)(91-109)(92-104)(92-110)(93-120)(94-124)(95-117)(95-118)(95-119)(96-121)(96-122)(96-123)(97-126)(98-125)(99-125)(100-126)(105-127)(106-127)(107-127)(108-127)(111-125)(112-125)(113-126)(114-126)(115-127)(116-127)(125-127)(126-127)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 82 | 49 | 10.1016/j.jinorgbio.2019.03.02... | 2019 |
| PC-3 | 82 | 86 | 10.1016/j.jinorgbio.2019.03.02... | 2019 |
| LNCaP | 86 | 8.9 | 10.1016/j.jinorgbio.2019.03.02... | 2019 |
| LNCaP | 86 | 75 | 10.1016/j.jinorgbio.2019.03.02... | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«The potential of these complexes to induce apoptosis in LNCaP cells was performed under light and dark conditions by Hoechst 33342 DNA staining and flow cytometry assay. ... the apoptotic rates induce...»