Info
| ID | 4069 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 4 b |
| SMILES | CC(C)c1c[c-]c(-n2cc3ccccc3n2)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C26ClN2Ru/(1-22)(2-23)(3-20)(4-20)(5-23)(6-8)(6-22)(7-10)(7-14)(8-19)(9-17)(9-19)(10-13)(11-12)(11-18)(12-26)(13-25)(14-21)(15-16)(15-26)(16-18)(17-22)(18-23)(19-20)(21-24)(21-25)(24-28)(25-27)(26-28)(27-28)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 8.2 | — | 10.1002/cplu.202000516 | 2020 |
| HeLa | 8.9 | — | 10.1002/cplu.202000516 | 2020 |
| A549 | 22 | — | 10.1002/cplu.202000516 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The new iridium complex 5b with isopropyl substituent in the phenyl ring of 2H-indazole moiety showed good activity against MCF-7 cells and show apoptosis with increased caspase-3/7 activity.»