Info
| ID | 403 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | JHOR10 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C1C(=O)c2cccnc2-c2ncccc21.[Cl-] |
TUCAN
C22H20N2O2Ru/(1-22)(2-25)(3-22)(4-24)(5-21)(6-21)(7-22)(8-21)(9-28)(10-30)(11-29)(12-31)(13-37)(14-38)(15-26)(16-23)(17-23)(18-23)(19-36)(20-27)(21-32)(22-36)(23-36)(24-25)(24-32)(25-33)(26-27)(26-33)(27-32)(28-30)(28-37)(29-31)(29-38)(30-34)(31-35)(33-36)(34-39)(34-41)(35-40)(35-42)(37-43)(38-44)(39-40)(39-43)(40-44)(41-42)(41-45)(42-46)(43-47)(44-47)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 1.2 | — | 10.3390/ijms232113594 | 2021 |
| A2780 | 5.3 | — | 10.3390/ijms232113594 | 2021 |
| HCT-116 | 5.5 | — | 10.3390/ijms232113594 | 2021 |
| HCT-116/Dox | 6.8 | — | 10.3390/ijms232113594 | 2021 |
| HCT-116 | 26 | — | 10.3390/ijms232113594 | 2021 |
| HCT-116/Dox | — | — | 10.3390/ijms232113594 | 2021 |
🧬 Cell Death Types (1)
Autophagy
high
«Studies in A2780 cells showed that JHOR11 induced the production of reactive oxygen species (ROS) that trigger autophagy and cellular senescence, but no apoptosis induction. Furthermore, 'suggesting t...»
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