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Complex #402 — Ru(2) [Ru-PIP]

2D Structure

Structure
⬇ MOL V3000

Info

ID402
MetalRu
Oxidation state2
Charge2
Donor atoms{"N": 6}
AbbreviationRu-PIP
SMILESc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1

TUCAN

C55H32N12Ru/(1-40)(2-66)(3-42)(4-65)(5-67)(6-50)(7-46)(8-33)(9-35)(10-37)(11-47)(12-39)(13-38)(14-44)(15-43)(16-68)(17-52)(18-41)(19-51)(20-49)(21-70)(22-48)(23-34)(24-53)(25-56)(26-54)(27-55)(28-45)(29-36)(30-69)(31-57)(32-93)(33-41)(33-75)(34-44)(34-66)(35-43)(35-59)(36-40)(36-49)(37-40)(37-62)(38-47)(38-63)(39-48)(39-69)(41-50)(42-50)(42-80)(43-65)(44-58)(45-51)(45-55)(46-55)(46-83)(47-70)(48-64)(49-57)(51-85)(52-54)(52-60)(53-56)(53-61)(54-67)(56-68)(57-62)(58-72)(58-76)(59-71)(59-77)(60-84)(60-86)(61-81)(61-82)(62-87)(63-74)(63-79)(64-73)(64-78)(65-94)(66-90)(67-92)(68-95)(69-97)(70-89)(71-76)(71-94)(72-77)(72-88)(73-74)(73-97)(74-89)(75-80)(75-96)(76-90)(77-96)(78-79)(78-99)(79-93)(80-88)(81-84)(81-95)(82-86)(82-98)(83-85)(83-91)(84-92)(85-98)(86-91)(87-93)(87-99)(94-100)(95-100)(96-100)(97-100)(98-100)(99-100)

Measurements (24)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HeLa11 10.1038/s41598-023-28454-x 2023
T2416 10.1038/s41598-023-28454-x 2023
HeLa19 10.1038/s41598-023-28454-x 2023
HeLa21 10.3390/pharmaceutics13020150 2021
T2423 10.1038/s41598-023-28454-x 2023
MCF-728 10.1038/srep31973 2016
A54928 10.3390/pharmaceutics13020150 2021
T2432 10.3390/pharmaceutics13020150 2021
HeLa34 10.1038/s41598-023-28454-x 2023
HeLa38 10.1038/srep31973 2016
HeLa40 10.3390/pharmaceutics13020150 2021
T2445 10.1038/s41598-023-28454-x 2023
T2452 10.3390/pharmaceutics13020150 2021
NCI-H197559 10.1038/s41598-023-28454-x 2023
A54960 10.3390/pharmaceutics13020150 2021
HeLa75 10.3390/pharmaceutics13020150 2021
T2486 10.3390/pharmaceutics13020150 2021
MRC-591 10.1038/s41598-023-28454-x 2023
NCI-H197595 10.1038/s41598-023-28454-x 2023
NCI-H1975 10.1038/s41598-023-28454-x 2023
MRC-5 10.1038/s41598-023-28454-x 2023
MRC-5 10.1038/s41598-023-28454-x 2023
A549 10.3390/pharmaceutics13020150 2021
HFF 10.1038/srep31973 2016

🧬 Cell Death Types (1)

Autophagy high
«quantifying LC3 levels revealed a distinct increase in the ratio of LC3-II to LC3-I, a hallmark of autophagy induction, in 2-treated cells from exposure times of 8h onwards»