Info
| ID | 4018 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 2 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C([N-]c1ccc(F)cc1)c1ccc2ccccc2n1.[Cl-] |
TUCAN
C26H24FN2ORu/(1-39)(2-25)(3-32)(4-31)(5-41)(6-25)(7-35)(8-37)(9-36)(10-29)(11-34)(12-28)(13-40)(14-30)(15-38)(16-26)(17-33)(18-26)(19-26)(20-27)(21-27)(22-45)(23-25)(24-27)(25-42)(26-45)(27-45)(28-35)(28-46)(29-39)(29-50)(30-40)(30-50)(31-32)(31-42)(32-43)(33-41)(33-43)(34-37)(34-44)(35-36)(36-38)(37-47)(38-44)(39-48)(40-48)(41-42)(43-45)(44-46)(46-52)(47-49)(47-52)(48-51)(49-51)(49-53)(50-54)(51-55)(52-55)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 18 | — | 10.1039/c6dt01464j | 2016 |
| A2780cisR | 22 | — | 10.1039/c6dt01464j | 2016 |
| HCT-116 | 39 | — | 10.1039/c6dt01464j | 2016 |
| ARPE-19 | — | — | 10.1039/c6dt01464j | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Apoptotic analyses revealed a clear correlation between chemosensitivity and levels of apoptosis, whereby the most active compound induces the highest percentage of apoptosis.»