Info
| ID | 4017 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 1 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C([N-]c1ccccc1F)c1ccc2ccccc2n1.[Cl-] |
TUCAN
C26H24FN2ORu/(1-40)(2-31)(3-26)(4-30)(5-45)(6-41)(7-36)(8-39)(9-33)(10-29)(11-38)(12-28)(13-35)(14-34)(15-37)(16-26)(17-25)(18-25)(19-32)(20-26)(21-27)(22-27)(23-25)(24-27)(25-42)(26-45)(27-45)(28-36)(28-47)(29-35)(29-50)(30-31)(30-42)(31-43)(32-41)(32-43)(33-36)(33-37)(34-35)(34-40)(37-44)(38-39)(38-44)(39-46)(40-48)(41-42)(43-45)(44-47)(46-49)(46-52)(47-52)(48-50)(48-51)(49-51)(49-53)(50-54)(51-55)(52-55)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| ARPE-19 | 4.3 | — | 10.1039/c6dt01464j | 2016 |
| A2780 | 4.8 | — | 10.1039/c6dt01464j | 2016 |
| HCT-116 | 6.7 | — | 10.1039/c6dt01464j | 2016 |
| A2780cisR | 12 | — | 10.1039/c6dt01464j | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Apoptotic analyses revealed a clear correlation between chemosensitivity and levels of apoptosis, whereby the most active compound induces the highest percentage of apoptosis.»