Info
| ID | 401 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | -2 |
| Donor atoms | {"N": 2} |
| Abbreviation | 2b |
| SMILES | O=C(O)c1cc2c(cn1)[nH]c1ccccc12.[Cl-].[Cl-].[Cl-].[Cl-] |
TUCAN
C12H8N2O2Ru/(1-12)(2-10)(3-16)(4-13)(5-9)(6-11)(7-21)(8-24)(9-11)(9-12)(10-12)(10-14)(11-17)(13-15)(13-19)(14-15)(14-17)(15-18)(16-18)(16-22)(17-21)(18-21)(19-20)(19-22)(20-23)(20-24)(22-25)(24-25)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 13 | — | 10.1186/s12951-021-00799-3 | 2021 |
| LLC | 56 | — | 10.1186/s12951-021-00799-3 | 2021 |
| 95D | 57 | — | 10.1186/s12951-021-00799-3 | 2021 |
| A549-TAX | 60 | — | 10.1186/s12951-021-00799-3 | 2021 |
| S180 | 92 | — | 10.1186/s12951-021-00799-3 | 2021 |
| LO2 | — | — | 10.1186/s12951-021-00799-3 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Compared with that in the normal group, cleaved PARP and cleaved caspase 3 expression increased significantly after incubation with 2b; ATM, γ-H2A.X and CDK1 expression decreased in a concentration-de...»