Info
| ID | 400 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 2a |
| SMILES | O=C(O)c1cc2c(cn1)[nH]c1ccccc12.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C32H24N6O2Ru/(1-44)(2-45)(3-26)(4-46)(5-27)(6-35)(7-38)(8-33)(9-41)(10-40)(11-25)(12-30)(13-32)(14-28)(15-29)(16-31)(17-39)(18-47)(19-36)(20-37)(21-34)(22-48)(23-57)(24-64)(25-26)(25-49)(26-27)(27-44)(28-30)(28-35)(29-41)(29-53)(30-50)(31-32)(31-38)(32-52)(33-40)(33-43)(34-42)(34-55)(35-45)(36-37)(36-39)(37-54)(38-46)(39-47)(40-41)(42-43)(42-51)(43-53)(44-58)(45-59)(46-60)(47-61)(48-51)(48-62)(49-50)(49-58)(50-59)(51-57)(52-54)(52-60)(53-57)(54-61)(55-56)(55-62)(56-63)(56-64)(58-65)(59-65)(60-65)(61-65)(62-65)(64-65)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| S180 | — | — | 10.1186/s12951-021-00799-3 | 2021 |
| LLC | — | — | 10.1186/s12951-021-00799-3 | 2021 |
| A549 | — | — | 10.1186/s12951-021-00799-3 | 2021 |
| A549-TAX | — | — | 10.1186/s12951-021-00799-3 | 2021 |
| 95D | — | — | 10.1186/s12951-021-00799-3 | 2021 |
| LO2 | — | — | 10.1186/s12951-021-00799-3 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Compared with that in the normal group, cleaved PARP and cleaved caspase 3 expression increased significantly after incubation with 2b; ATM, γ-H2A.X and CDK1 expression decreased in a concentration-de...»