Info
| ID | 3972 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 4 |
| SMILES | Cc1ccc(-n2cc(-c3cn(-c4ccc(C)cc4)nn3)nn2)cc1.[Cl-].c1ccccc1 |
TUCAN
C24H22N6Ru/(1-25)(2-35)(3-24)(4-26)(5-27)(6-38)(7-24)(8-32)(9-34)(10-37)(11-28)(12-29)(13-30)(14-31)(15-24)(16-42)(17-41)(18-36)(19-23)(20-23)(21-23)(22-33)(23-39)(24-40)(25-32)(25-43)(26-27)(26-28)(27-29)(28-30)(29-31)(30-31)(32-39)(33-36)(33-39)(34-35)(34-40)(35-44)(36-43)(37-38)(37-40)(38-44)(41-45)(41-48)(42-46)(42-49)(43-48)(44-49)(45-46)(45-47)(46-51)(47-50)(48-50)(49-52)(51-52)(51-53)(52-53)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | — | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
| HCT-116 | — | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
| HCT-116/Dox | — | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«compounds 1 and 3 induced apoptosis in approximately 17% and 37% of A2780 cells.»
Autophagy
high
«compound 1 can induce autophagic death in 80% of A2780 cells»