Info
| ID | 3971 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 3 |
| SMILES | Cc1ccc(-n2cc(-c3ccccn3)nn2)cc1.[Cl-].c1ccccc1 |
TUCAN
C20H18N4Ru/(1-19)(2-34)(3-20)(4-21)(5-22)(6-31)(7-28)(8-23)(9-24)(10-25)(11-26)(12-27)(13-29)(14-35)(15-30)(16-19)(17-19)(18-32)(19-33)(20-21)(20-22)(21-23)(22-24)(23-25)(24-25)(26-28)(26-33)(27-31)(27-34)(28-38)(29-31)(29-36)(30-32)(30-33)(32-38)(34-41)(35-37)(35-39)(36-37)(36-41)(37-42)(38-39)(39-40)(40-42)(41-43)(42-43)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 7.3 | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
| HCT-116 | — | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
| HCT-116/Dox | — | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«compounds 1 and 3 induced apoptosis in approximately 17% and 37% of A2780 cells.»
Autophagy
high
«compound 1 can induce autophagic death in 80% of A2780 cells»