Info
| ID | 3970 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 2 |
| SMILES | Cc1ccc(-n2cc(-c3cn(-c4ccc(C)cc4)nn3)nn2)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C28H30N6Ru/(1-41)(2-39)(3-52)(4-31)(5-32)(6-36)(7-31)(8-37)(9-31)(10-33)(11-44)(12-40)(13-42)(14-38)(15-33)(16-33)(17-47)(18-34)(19-45)(20-53)(21-34)(22-34)(23-54)(24-46)(25-32)(26-32)(27-35)(28-35)(29-35)(30-43)(31-52)(32-49)(33-52)(34-50)(35-51)(36-37)(36-48)(37-49)(38-42)(38-48)(39-40)(39-55)(40-50)(41-44)(41-58)(42-49)(43-45)(43-50)(44-51)(45-55)(46-47)(46-51)(47-58)(48-52)(53-57)(53-60)(54-56)(54-61)(55-60)(56-57)(56-63)(57-59)(58-61)(59-62)(60-62)(61-64)(63-64)(63-65)(64-65)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 48 | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
| HCT-116 | — | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
| HCT-116/Dox | — | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«compounds 1 and 3 induced apoptosis in approximately 17% and 37% of A2780 cells.»
Autophagy
high
«compound 1 can induce autophagic death in 80% of A2780 cells»