Info
| ID | 3969 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 1 |
| SMILES | Cc1ccc(-n2cc(-c3ccccn3)nn2)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C24H26N4Ru/(1-46)(2-27)(3-28)(4-28)(5-45)(6-28)(7-29)(8-27)(9-29)(10-32)(11-31)(12-29)(13-37)(14-40)(15-34)(16-30)(17-39)(18-30)(19-38)(20-27)(21-36)(22-33)(23-41)(24-35)(25-30)(26-47)(27-43)(28-45)(29-45)(30-44)(31-32)(31-43)(32-42)(33-36)(33-42)(34-37)(34-48)(35-41)(35-48)(36-43)(37-44)(38-39)(38-46)(39-40)(40-49)(41-44)(42-45)(46-53)(47-50)(47-51)(48-51)(49-50)(49-53)(50-54)(51-52)(52-54)(53-55)(54-55)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 7.6 | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
| HCT-116 | 12 | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
| HCT-116/Dox | — | — | 10.1021/acs.inorgchem.1c00527 | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«compounds 1 and 3 induced apoptosis in approximately 17% and 37% of A2780 cells.»
Autophagy
high
«compound 1 can induce autophagic death in 80% of A2780 cells»