Info
| ID | 3953 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "P": 2} |
| Abbreviation | 3 |
| SMILES | Cc1ccc(-c2ccc(C)cn2)nc1.Cn1ccnc1.[Cl-].c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C44H46N4P2Ru/(1-73)(2-51)(3-50)(4-73)(5-85)(6-54)(7-55)(8-49)(9-52)(10-47)(11-53)(12-72)(13-74)(14-59)(15-85)(16-65)(17-56)(18-58)(19-78)(20-81)(21-77)(22-84)(23-86)(24-60)(25-66)(26-68)(27-74)(28-86)(29-61)(30-62)(31-69)(32-57)(33-63)(34-70)(35-67)(36-64)(37-71)(38-77)(39-77)(40-79)(41-80)(42-47)(43-47)(44-48)(45-48)(46-48)(47-75)(48-76)(49-51)(49-87)(50-51)(50-55)(52-53)(52-82)(53-75)(54-59)(54-65)(55-56)(56-87)(57-66)(57-68)(58-59)(58-88)(60-65)(60-88)(61-66)(61-89)(62-68)(62-89)(63-69)(63-90)(64-70)(64-90)(67-69)(67-70)(71-72)(71-76)(72-83)(73-74)(73-85)(74-86)(75-79)(76-80)(77-91)(78-81)(78-92)(79-93)(80-94)(81-91)(82-83)(82-93)(83-94)(84-91)(84-92)(85-95)(86-96)(87-95)(88-95)(89-96)(90-96)(92-97)(93-97)(94-97)(95-97)(96-97)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 15 | — | 10.1016/j.jinorgbio.2018.06.00... | 2018 |
| CCD-1059Sk | 36 | — | 10.1016/j.jinorgbio.2018.06.00... | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex (3) inhibited the clonogenic capacity and cell cycle progression of A549 cells and induced apoptosis involving mitochondrial pathway activation.»