Info
| ID | 3895 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | 11 (SMe) |
| SMILES | CSc1ccccc1N=P(c1ccccc1)(c1ccccc1)c1cc2ccccc2[n-]1.Cc1ccc(C(C)C)cc1 |
TUCAN
C37H36N2PRuS/(1-37)(2-41)(3-37)(4-52)(5-46)(6-40)(7-37)(8-42)(9-38)(10-49)(11-44)(12-43)(13-66)(14-62)(15-50)(16-54)(17-38)(18-39)(19-56)(20-53)(21-55)(22-38)(23-59)(24-60)(25-72)(26-72)(27-58)(28-51)(29-47)(30-39)(31-39)(32-61)(33-57)(34-48)(35-45)(36-72)(37-66)(38-66)(39-64)(40-41)(40-63)(41-64)(42-55)(42-63)(43-44)(43-46)(44-50)(45-51)(45-65)(46-69)(47-48)(47-67)(48-51)(49-50)(49-69)(52-65)(52-71)(53-54)(53-70)(54-62)(55-64)(56-61)(56-62)(57-58)(57-68)(58-59)(59-60)(60-73)(61-70)(63-66)(65-67)(67-74)(68-73)(68-75)(69-76)(70-76)(71-74)(71-76)(72-77)(73-77)(74-78)(75-76)(75-78)(77-78)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.87 | — | 10.1039/d0nj04958a | 2020 |
| PC-3 | 1.1 | — | 10.1039/d0nj04958a | 2020 |
| SiHa | 2.4 | — | 10.1039/d0nj04958a | 2020 |
| HFF | 6.9 | — | 10.1039/d0nj04958a | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2.»