Info
| ID | 3893 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | 9 (SPh) |
| SMILES | Cc1ccc(C(C)C)cc1.c1ccc(Sc2ccccc2N=P(c2ccccc2)(c2ccccc2)c2cc3ccccc3[n-]2)cc1 |
TUCAN
C42H38N2PRuS/(1-44)(2-45)(3-42)(4-47)(5-49)(6-56)(7-52)(8-48)(9-53)(10-58)(11-51)(12-54)(13-43)(14-60)(15-57)(16-65)(17-66)(18-59)(19-69)(20-63)(21-55)(22-64)(23-61)(24-62)(25-46)(26-68)(27-39)(28-40)(29-40)(30-50)(31-40)(32-39)(33-41)(34-41)(35-73)(36-39)(37-67)(38-41)(39-70)(40-73)(41-73)(42-45)(42-76)(43-46)(43-74)(44-45)(44-58)(46-53)(47-49)(47-70)(48-51)(48-60)(49-71)(50-67)(50-71)(51-63)(52-53)(52-72)(54-59)(54-62)(55-72)(55-78)(56-58)(56-76)(57-59)(57-77)(60-80)(61-62)(61-77)(63-69)(64-65)(64-68)(65-66)(66-79)(67-70)(68-75)(69-80)(71-73)(72-74)(74-81)(75-79)(75-82)(76-83)(77-83)(78-81)(78-83)(79-84)(80-84)(81-85)(82-83)(82-85)(84-85)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.83 | — | 10.1039/d0nj04958a | 2020 |
| PC-3 | 3.3 | — | 10.1039/d0nj04958a | 2020 |
| SiHa | 4 | — | 10.1039/d0nj04958a | 2020 |
| HFF | 8.2 | — | 10.1039/d0nj04958a | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2.»